Black Hole (T1 Lesions)

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A black hole is a plaque in the brain that emits a low signal in an MRI scan. Technically, the low signals are called T1 hypointense lesions. Their presence indicates that the disease has progressed at a severe pace and that not only has myelin been destroyed, but the axons themselves have been obliterated. The darker the spot, the more tissue damage has occurred. Black holes form in areas where inflammation and plaques have occurred again and again. The area is totally inactive.

  • People with black holes have permanent disabilities.
  • Some scientists think that these black holes may actually be deposits of iron.

[edit] Studies

  • “Evolution of T1 Black Holes in Patients with Multiple Sclerosis Imaged Monthly for 4 Years.” Brain. 2003 Aug;126(Pt 8):1782-9. Epub 2003 Jun 23.
  • “Disappearing ‘T1 Black Holes’ in an Animal Model of Multiple Sclerosis.”

Front Biosci. 2004 May 1;9:1222-7.

  • “Hypointense Multiple Sclerosis Lesions on T1-Weighted Spin Echo Magnetic Resonance Images: Their Contribution in Understanding Multiple Sclerosis Evolution.”

J Neurol Neurosurg Psychiatry. 1998 May;64 Suppl 1:S77-9.

[edit] Sources

“Betaseron (Interferon Beta-1b) Therapy Delays Axonal Damage in Secondary Progressive Multiple Sclerosis.” 2 May 2000. 11 Aug. 2004 <>. King, Martha. “Bright Spots and Black Holes: What Doctors are Learning from Advanced MRI.” Inside MS. 20.4 (2002). 11 Aug. 2004 <>.

Simon, Harvey, ed. “What Tests Are Used to Diagnose Multiple Sclerosis?” UC Davis Health System. 31 Dec. 2002. 11 Aug. 2004 < /healthconsumers/health/000017.shtml#>.

For information purposes only. For specific advice and opinion, always consult a physician.
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